Solid-phase extraction, commonly referred to the acronym SPE, is an extraction technique that uses the affinity of a solid substance (solid phase), generally packed in columns or disks, with one or more substances present in a more or less complex matrix.

The Solid-Phase Extraction (SPE) sample preparation method was developed by a combination of extraction and chromatography. It is mainly used for separation, purification, and concentration of samples. It has found applications in environmental protection, food, petrochemical, clinical drug analysis, life sciences, etc.